Ebola virus disease: An update on current prevention and management strategies.
Identifieur interne : 000D67 ( Main/Exploration ); précédent : 000D66; suivant : 000D68Ebola virus disease: An update on current prevention and management strategies.
Auteurs : M A Trad [France] ; W. Naughton [Australie] ; A. Yeung [Australie] ; L. Mazlin [Belgique] ; M. O'Sullivan [Australie] ; N. Gilroy [Australie] ; D A Fisher [Singapour] ; R L Stuart [Australie]Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2017.
Abstract
Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses, and high mortality in under-resourced settings. There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014-15 outbreak, in which 20 (80%) out of 25 patients survived. Emerging data from current trials look promising and are undergoing further study, however optimised supportive care remains the key to reducing mortality from EVD.
DOI: 10.1016/j.jcv.2016.11.005
PubMed: 27893999
Affiliations:
- Australie, Belgique, France, Singapour
- Nouvelle-Galles du Sud, Région de Bruxelles-Capitale, Île-de-France
- Bruxelles, Paris, Sydney
- Université de Sydney, Université nationale de Singapour
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There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014-15 outbreak, in which 20 (80%) out of 25 patients survived. Emerging data from current trials look promising and are undergoing further study, however optimised supportive care remains the key to reducing mortality from EVD.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>Singapour</li></country><region><li>Nouvelle-Galles du Sud</li><li>Région de Bruxelles-Capitale</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Trad, M A" sort="Trad, M A" uniqKey="Trad M" first="M A" last="Trad">M A Trad</name></region></country><country name="Australie"><noRegion><name sortKey="Naughton, W" sort="Naughton, W" uniqKey="Naughton W" first="W" last="Naughton">W. Naughton</name></noRegion><name sortKey="Gilroy, N" sort="Gilroy, N" uniqKey="Gilroy N" first="N" last="Gilroy">N. Gilroy</name><name sortKey="O Sullivan, M" sort="O Sullivan, M" uniqKey="O Sullivan M" first="M" last="O'Sullivan">M. O'Sullivan</name><name sortKey="Stuart, R L" sort="Stuart, R L" uniqKey="Stuart R" first="R L" last="Stuart">R L Stuart</name><name sortKey="Yeung, A" sort="Yeung, A" uniqKey="Yeung A" first="A" last="Yeung">A. Yeung</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Mazlin, L" sort="Mazlin, L" uniqKey="Mazlin L" first="L" last="Mazlin">L. Mazlin</name></region></country><country name="Singapour"><noRegion><name sortKey="Fisher, D A" sort="Fisher, D A" uniqKey="Fisher D" first="D A" last="Fisher">D A Fisher</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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